All posts by Bernhard

Community, Conversations, Disease, Featured, Integrative Omics, Patient Centric

Considerations from the Frontline for Infectious Disease – COVID-19 Pandemic

7th Annual Brasilian Symposium on Clinical & Pharmaceutical Solutions through Analysis (CPSA BRASIL 2020)

Program Chair – CPSA Brazil 2020
Carlos Kiffer, MD, Ph.D. from Escola Paulista de Medicina / Universidade Federal de São Paulo

“We’re responsible for ourselves as much as we are responsible for our communities.”

“(What COVID-19 brought us) A chance of observing a large number of patients over a small period of time. You start to see patterns.”

“I wish everyone could take care of each other.”

Diseases are complex, and the COVID-19 pandemic presents with several manifestations.  Working in infectious disease for over 30 years, Carlos has observed 100’s to 1000’s of patients and works with friends and colleagues to identify patterns related to these different manifestations.  They work together to make sense of these patterns through observations of patients in the hospitals, as well as using metabolomics, proteomics, and genetics to measure molecular differences in manifestations.  The global pandemic will bring changes to certain approaches used for understanding infectious disease, and Carlos passionately works with community to bring relevant knowledge to design clinical scoring systems to define the spectrum of COVID-19 manifestations.

Clinical, Conversations, Education, Featured, Metabolomics, Patient Centric

Considerations on Metabolomics and Integrative Omics – COVID-19 Response and Post Recovry Diseases

7th Annual Brasilian Symposium on Clinical & Pharmaceutical Solutions through Analysis (CPSA BRASIL 2020)

Roundtable Session Coordinator – CPSA Brazil 2020
Regina Oliveira, Ph.D. from Universidade Federal de São Carlos

“My passion is to know that I can make a difference.”

“[Make the general public] feel more comfortable knowing that it will pass, and that science will help them find the solution, to take away from health problem”

“Need to think about the disease (COVID-19) after recovery.”

In a response to a pandemic such as COVID-19, Regina looks to not only collect relevant data from patient samples – she also educates her family, friends, and community that we will get through this crisis together. Along with education with generating accurate knowledge, her lab (among many projects) works on diseases related to COVID-19 that appear months to years after the infection and recovery. The knowledge is created through clinical research with metabolomics – a technology that has been on the front line for COVID-19 patients that present other diseases post recovery. Although complex in nature, Regina creates understandable biological knowledge that is helping patients – and can be shared with the population as a whole.

Roundtable Session – Lead by Regina Oliveira, Ph.D

Gustavo Simões, CEO Nanox, São Carlos, São Paulo, Brazil

Markus Schreyer, CEO & Founder, Ganeshalab

Valdemir Carvalho, Ph,D, Senior Scientific Consultant at Fleury Group, São Paulo, Brazil

Roundtable Contributors
Gustavo Mendes Lima Santos
Carlos Kiffer, MD, Ph.D.
Marc Chalom

Conversations, Disease, Featured, Patient Centric, Proteomics, Solutions

Considerations on Top Down Proteomics – Development of Diagnosis Tests for Patient

7th Annual Brasilian Symposium on Clinical & Pharmaceutical Solutions through Analysis (CPSA BRASIL 2020)

Proteomics Session Coordinator – CPSA Brazil 2020
Rafael Melani, Ph.D. from Northwestern University

“The development of new technology… of one specific protein can (lead to a) new diagnostic test.”

A passionate explanation of the love to help develop science and methodologies, even in little steps, to increase understanding of human disease with relevant biological knowledge. Technology continues to improve, and Top Down Proteomics (analysis of intact proteins) has developed into a technique that can be used to identify proteins that are involved with complex diseases, such as Cancer described in this CPSA Everyday. Much like people in society, proteins interact in networks working together, or possibly not working in unison. Understanding the complex protein networks help identify disease pathways that lead towards improved health outcomes for patients – with improved data to build relevant biological knowledge.

Proteomics Session Coordinator – Rafael Melani, PhD

Prof. Gilberto Domont, Emeritus Professor, Universidade Federal do Rio de Janeiro

Luca Fornelli, Ph.D, Assistant Professor of Biology, The University of Oklahoma, OK

Roundtable Contributors
Carlos Kiffer, MD, Ph.D.
Marc Chalom